Biochemistry quiz

Which of the following are characteristics of a good leaving broup?

• Already protonated

• Stable

• Has a weak conjugate acid

• conjugate acid has a low pKa

Which reaction(s) involve an intermediate?

• SN1

• SN2

• Ester hydrolysis

• Esterification

• Electrophilic addition

Which reaction(s) involve a tetrahedral intermediate?

• SN1

• Electrophillic addition

• Peptide bond hydrolysis

• Glycosidic bond hydrolysis

Is carbonation a transition state or an intermediate?

• Transition state

• Intermediate

Is carbocation a transition state or an intermediate?

• Transition state

• Intermediate

Which of the following might stabilise a carbonation?

• Adjacent alkyl groups

• Adjacent benzylic group

• Adjacent electron - withdrawing group

• Adjacent lone pair

Which amino acid is not found in the catalytic triad

• Histidine

• Aspartic acid

• Serine

• Proline

Which one is the strongest nucleophile?

• hydroxide

• ethoxide

• cyanide

• ammonia

Which of the following is/are not true statement(s) about enzymes.

• Destabilise the substrate

• Covalently interact with the intermediate

• Form the strongest interaction with substrate

• Form hydrophobic interaction with the substrate