Experiment 14 ：Reductive Amination

What might happen if saturated sodium bicarbonate was NOT added to the mixtureduring workup?

• The product might be protonated by acetic acid and dissolve in the aqueous layer

• The product might be converted back tothe starting materials

• Carbon dioxide might be eliminated during workup

• The remaining sodium borohydride might explode

Which of the following is an intermediate product in reductive amination?

• imine

• amine

• hydrazine

• amide

Which compound is eliminated in reductive amination?

• hydrogen

• ammonia

• water

• carbon dioxide

What solvent will we use when reacting vanillin and p-toluidine?

• acetic acid

• No solvent will be added when reacting vanillin and p-toluidine

• ethanol

• ethyl acetate

The number of mmol of sodium borohydride added is less than the number of mmol of vanillin and para-toluidine used, why?

• We do not have enough sodium borohydride in stock

• If excess sodium borohydride is used, the product will be decomposed

• More than one hydrogen in NaBH4 can react in the reduction of imine

• We do not want the reaction to go to completion