Practice tutor week 2

Which of the following term

may be used to calculate the AUC from zero to inifinity

• Co/kel

• Vd*kel

• 
  Cp(last)/kel

• Dose/Co

Which of the following is true

about trapezoid rule of calculating

the AUC for a drug after an IV

bolus

• It utilizes urinary excretion

  data in the calculation

• It over the estimates the

  actual AUC

• It is not valid for first-order

  elimination

• It under estimates the actual AUC

A patient received an intravenous bolus dose containing 500mg cefamandole nafate. The plasma drug concentration at 1 hours and 5 hours after the dose was 1.2mg/L and 0.3mg/L, respectively. Drug elimination is first order according to a one-compartment model. Calculate the plasma drug concentration (in mg/L) at 9 hours after the dose.

• 0.075

• 4.896

• 0.3466

• 1.697

An IV bolus dose (300 mg) of drug with a known elimination half-life of 4 hours was administered to a patient and the plasma drug concentration 1 hour later was found to be 5 mg per liter. The drug is also known to be eliminated according to a 1-compartment open model with first-order kinetics. Calculate the plasma drug concentration (in mcg/mL) at 3 hours after the dose (3 sig)

• 3.54

• 5.95

• 4.54

• 2.95

A patient received an intravenous bolus dose containing 500mg cefamandole nafate. The plasma drug concentration at 1 hours and 5 hours after the dose was 1.2mg/L and 0.3mg/L, respectively. Drug elimination is first order according to a one-compartment model. Calculate the initial plasma concentration.

• 1.697

• 0.3466

• 0.075

• 4.896