Biochem CH5

____:

Dissociation constant, lower ___ indicates a stronger affinity whereas a higher ___ indicates more dissociation between ligand and protein

____ is a general term for functional non-amino acid components, such as metal ions or organic molecules.

____ is used to designate an organic cofactor.

_____ ____ are contently attached cofactors. (ex. Heme in myoglobin).

_______:

   Has a tetrameric structure, 2 alpha chains (141AA) 2 betas (145 AA) and 4 heme groups.

Hemoglobin:

   __ state is present in low concentrations of O2 and is what releases oxygen into the tissue

▪    More stable without O2

▪    Heme iron is protruding on proximal histidine

▪    Has donut hole

Hemoglobin:

__ state higher affinity, O2 binding stabilizes it.

____ is the average Kd value for all the binding sites.

  ____ is the Hill coefficient which characterizes the degree of cooperativity.

nh > _ The system shows positive cooperativity