Ivabradine 19-10-2023

Full form of MRS done with ivabradine of which results were published in IJAM in July 2023

• Marketing Research Survey

• Milestone Research Survey

• Model Research Survey

• Medical Research Survey

To Understand clinicians’ perspectives regarding HF management with an emphasis on HR optimization comes under which study

• MRS

• Ivabid OD PMOS

• Initiate OD Study

Relative bioavailability study was done with Ivabradine ____mg OD compared to ___mg BID in 14 healthy human male subjects.

• 10, 5

• 15, 7.5

• 5, 10

• 7.5, 15

Proficient study was a Prospective, Randomized, Double-blind, Double Dummy, Multi Centre, Comparative Phase _____ Clinical Trial To Evaluate The Efficacy And Safety Of Ivabradine Prolonged Release Tablets In Patients With Stable Chronic Heart Failure With Systolic Dysfunction

• I

• II

• III

• IV

The non-inferiority criteria in Proficient study was that the difference in change in resting HR parameter between PR and IR treatments should not be more than _____ bpm.

• 2

• 4.5

• 6.5

• 7.5

In Proficient study, Primary end point of _____________of Ivabradine PR was established to the conventional IR formulation in patients with stable chronic heart failure with systolic dysfunction on stable dose of Ivabradine IR.

• Superiority

• Non-inferiority

Cardiac Pacemaker current (If) is a mixed sodium-potassium ________ current that controls the spontaneous diastolic depolarization in the sinoatrial (SA) node and hence regulates the heart rate.

• Outward

• Inward

As per results of MRS with Ivabradine, 46.3% of clinicians noticed a ______ bpm reduction in HR at the highest therapeutic dosage of ivabradine,

• 2 to 3

• 4 to 5

• 6 to 10

• None of these

Majority of patients in MRS with ivabradine belong to the New York Heart Association (NYHA) categories ___ and ___, with ischemia being the most prevalent cause of HF.

• I & II

• II & III

• III & IV

• I & IV

In patients with HFrEF on ivabradine therapy, 43.6% of clinicians revealed that they _________ up-titrated ivabradine dose to 15 mg per day.

• Rarely

• Very Frequently

• Frequently

• Occasionally