Med Chem: Toxicology Part II

Select all of the cellular defenses against oxygen toxicity

• antioxidant scavenging enzymes

• nonenzymatic antioxidants

• compartmentalization and metal sequestration

• repair of damaged components

free radical scavengers

• enzymes

• nonenzymatic antioxidants

SOD (superoxide dismutase) and GSH (glutathione)

• defenses against nitrogen containing free radicals

• defenses against oxygen toxicity

Superoxide dismutase (SOD) and catalase

• compartmentalization and metal sequestration

• nonenzymatic antioxidants

• antioxidant scavenging enzymes

Converts O2(-) ---> H2O2

• SOD (superoxide dismutase)

• Catalase

Reduces H2O2 --> H2O and prevents hydroxyl radical formation

• SOD (superoxide dismutase)

• catalase

GSH

• antioxidant enzymes

• antioxidant scavenging enzymes

reduces H2O2 to H2O

• glutathione peroxidase

• SOD

miscellaneous nonenzymatic antioxidants

• vitamin C

• carotenoids

• flavonoids

• vitamin E

Common causes of pathology and death in acutely poisoned patient.

• shock

• hypovolemia

• hypothermia

• cellular hypoxia