RegulationOFp53levels

Phosphorylates serine-15 of p53 which plays a role in its binding to transcriptional coactivator CBP

• Chk2 kinase

• Mdm2

• Ubiquitin

• ATM kinase

Which enzyme produces nicks in damaged DNA strands?

• Ubiquitin

• ATM kinase

• Repair endonuclease

• Chk2 kinase

What is the main function of ATM kinase?

• Phosphorylates serine-20 of p53

• Repairs single and double strand breaks in DNA

• Attaches ubiquitins to p53

• Activates Chk2 kinase

Directly activates Chk2 kinase

• Mdm2

• Ubiquitin

• Repair endonuclease

• ATM kinase

What is the function of Mdm2?

• Activates ATM kinase

• Blocks Mdm2 action

• Binds to transcriptional coactivator CBP

• Attaches ubiquitins to p53

What is the covalent tag attached to lysines that targets proteins for proteolysis?

• ATM kinase

• Chk2 kinase

• Ubiquitin

• Mdm2

Which enzyme attaches ubiquitins to p53?

• ATM kinase

• Mdm2

• Repair endonuclease

• Chk2 kinase

What most directly activates ATM kinase

• Repair endonuclease

• Single and double strand breaks in DNA

• ATM kinase

• Chk2 kinase