Pharm Final Exam: 2 Compartment Model

A drug in the blood stream distributes to the tissues in the body.

• True

• False

All tissues typically take up drug at the same rate.

• True

• False

Answer explanation

The rate of blood perfusion to the tissue is what determines the rate it takes up a drug.

Imaginary unit in which different tissues with similar rates of drug uptake are grouped together.

• Compartment

• not this

A compartment is a homogenous unit.

• True

• False

Answer explanation

the drug concentration is uniform throughout at all times.

Due to ADME, drug conc. in a compartment is continuously changing with time.

Pharmacokinetic models use differential equations to describe the rate of change in drug conc.

Select all that is true for a homogenous compartment model.

• the drug conc. is uniform throughout at all times

• due to ADME, drug conc in a compartment is continuously changing with time

• Pharmacokinetic models use differential equations to describe the rate of change in a drug

Amount/volume describes

• concentration

• volum of distribution

• elimination

PK models do all of the following

• describe the rate of movement of drug between compartments

• explain the relationship of drug concentration with time after drug dose

• predict the time-course of drugs in the body

• summarize data

Why is it important to predict the time-course of drugs in the body.

• to allow us to maintain drug concentration in the therapeutic range to monitor.

• not this

Clinically observed plasma concentration- time profiles can be described as:

• one compartment

• two compartment

• three compartment

• four compartment

What is a three compartment model useful for?

• Oral drugs

• sedative drugs

• mammillary distribution