Ceradan Advanced Cream Barrier 2 Study

Where are serine proteases located?

• stratum basale

• stratum spinosum

• stratum granulosum

• stratum lucidum

• stratum corneum

What are the 2 key ways that proteases exert biological effects?

1) Direct ________ effect

What are the 2 key ways that proteases exert biological effects?

2) Activation of ____ signalling

Serine proteases play a key role in skin barrier homeostasis. How does increased skin pH and resulting protease and PAR-2 signalling affect lipid processing enzymes?

• Increased degradation of lipid processing enzymes

• Decreased degradation of lipid processing enzymes

Serine proteases play a key role in skin barrier homeostasis. How does increased skin pH and resulting protease and PAR-2 signalling affect lamellar bodies secretion

• Increased lamellar bodies secretion

• Decreased lamellar bodies secretion

Serine proteases play a key role in skin barrier homeostasis. How does increased skin pH and resulting protease and PAR-2 signalling affect lipid synthesis

• Increased lipid synthesis

• Decreased lipid synthesis

Serine proteases play a key role in skin barrier homeostasis. How does increased skin pH and resulting protease and PAR-2 signalling affect desquamation

• Increased desquamation

• Decreased desquamation

Elevated skin pH is a hallmark of persistent AD

• True

• False

Elevated skin pH in non-lesional AD skin (aside from lesional skin) highlighted the presence of skin defect even in the absence of clinical inflammation

• True

• False

What is the duration of BARRIER 2 study?

• 4 weeks

• 6 weeks

• 8 weeks

• 10 weeks