pk exam 2: Drug Elim & Hepatic CL part 1 stopped at 1-27

Drugs eliminated unchanged through the kidney.

• renal clearance

• hepatic clearance

drugs eliminated by metabolism in the liver

• renal clearance

• hepatic clearance

Renal clearance and hepatic clearance are ____ on/of each other

• dependent

• independent

Answer explanation

and they are additive

Drugs that are eliminated by _____ display large inter-individual variability due to genetic and environmental factors.

• renal clearance

• hepatic metabolism

Drugs that are eliminated by _____ are highly dependent on the glomerular filtration rate and blood flow to the kidney

• renal clearance

• hepatic metabolism

Which displays LESS ineter-individual variability?

• renal clearance

• hepatic metabolism

Answer explanation

GFR is relatively constant among healthy individuals. There is a "normal" measurement for GFR.

If renal excretion pathway becomes impaired What will become the primary drug elimination route?

• renal clearance

• hepatic metabolism

Answer explanation

more heavily reliant on the liver.

the opposite is true if the liver is damaged.

How can we calculate elimination rate constant (k)?

• from half life

• not this

Answer explanation

t1/2 = 0.693/k

fraction of a dose excreted unchanged in urine.

• ke

• fe

• F

Answer explanation

fe=ke/k

elimination rate constant due to excretion

• ke

• fe

• F