OCHEMII CH17

What nucleophile is best used for aldol addition?

In the presence of which base does the aldol addition of ketones typically proceed?

Which of the following conditions is not suitable for an aldol addition reaction?

• Basic medium

• Acidic medium

• Presence of a strong nucleophile

• Absence of a nucleophile

Which of the following is a product of aldol addition?

• Ketone

• Alkene

• Beta-hydroxy aldehyde

• Alpha-hydroxy ketone

Aldol addition is typically followed by which of these reactions in an aldol condensation?

• Reduction

• Dehydration

• Hydrogenation

• Halogenation

Which of the following is not a characteristic of aldol addition reactions?

• Formation of a new carbon-carbon bond

• Involvement of a carbonyl compound

• Use of a strong electrophile as the starting material

• Use of a base or nucleophile

When alkylating the alpha carbon, which conditions are best?

• 1. LDA/THF

  2. RCH2X

• -OH

• H3O+

• 1. NaBH4

  2.MeOH