Medicinal Biochemistry- Metabolism of Cholesterol & Amino acids

What is the approximate amount of free amino acids in the adult body's amino acid pool?

• 50 g

• 75g

• 100g

• 150g

Which amino acids constitute approximately 50% of the body's amino acid pool?

• Glutamate and glutamine

• Phenylalanine and tyrosine

• Glycine and alanine

• Leucine and lysine

How are amino acids transported into cells against a concentration gradient?

• Passive diffusion

• Facilitated diffusion

• Active transport

• Osmosis

Which factor influences the turnover of proteins in the body?

• Ubiquitin

• Half-life

• PEST sequence

• All of the above

How are excess amino acids metabolized in the body?

• Stored as glycogen

• Converted to urea and excreted

• Converted to ATP

• Stored as triglycerides

What provides all the carbon atoms in cholesterol synthesis?

• Acetate

• Acetyl CoA

• ATP

• NADPH

Which enzyme catalyzes the reduction of HMG CoA to mevalonate?

• HMG CoA reductase

• Acetyl CoA synthase

• HMG CoA synthase

• Lecithin-cholesterol acyltransferase

Which form of HMG CoA reductase is more active?

• Phosphorylated form

• Dephosphorylated form

• Oxidized form

• Reduced form

Which molecule serves as the precursor for cholesterol synthesis?

• Lanosterol

• Squalene

• Geranyl pyrophosphate

• Dimethylallyl pyrophosphate

How many moles of ATP are required for the production of one mole of cholesterol?

• 12

• 18

• 24

• 36