Predictive Methods Using DNA Sequences Quiz-2

What does FGENEH stand for?

• Michael Zhang's Exon Finder

• Cold Spring Harbor Laboratory

• Chris Burge and Sam Karlin

• Linear discriminant analysis

What technique does MZEF rely on for predictions?

• Probabilistic model

• Quadratic discriminant analysis

• Linear discriminant analysis

• Dynamic programming algorithm

What does GENSCAN predict in gene structures?

• Initial exons and terminal exons

• Introns and exons

• 3' and 5' splice sites

• PolyA regions and branch sites

What is the main purpose of FGENES?

• To make predictions for partial genes

• To determine gene structure descriptions

• To identify complete gene structures

• To predict internal coding exons

What is the total number of predicted genes and exons in the FGENES output using the human BAC clone from 7q31 as the query?

• 5 genes and 30 exons

• 3 genes and 27 exons

• 2 genes and 33 exons

• 4 genes and 25 exons

What are the measured variables used by MZEF for predictions?

• Probabilistic model of genomic sequence composition

• PolyA regions, initial exons, and terminal exons

• 3' and 5' splice sites, and exon, strand, and frame scores

• Exon length, intron-exon transitions, and branch sites

What is the main feature of the Sanger Centre Web server for FGENES?

• Ability to predict complete gene structures

• Identification of suboptimal exons

• Access to multiple gene predictions

• Simple front-end for performing predictions

What is the main advantage of GENSCAN for gene identification?

• Reliance on linear discriminant analysis

• Accurate predictions for single exons

• Identification of optimal exons only

• Ability to predict multiple genes separated by intergenic DNA

What is the main limitation of MZEF in gene prediction?

• Geared toward finding single exons

• Inability to predict internal coding exons

• Reliance on a probabilistic model

• Lack of information with respect to gene structure