7/10 Discussion

Which of the following is NOT a characteristic of inflammation?

• Production of functional BCR

• Redness

• edema

• Pain

Which of the following PRRs lead to the production of IFNS?

• A. RIG-I

• B. TLR4

• C. IL-1 Beta

• A and B

• A, B, and C

The process of __ results in the amplification of particular T cells or B cells with specificty for the antigen

• Allelic exclusion

• Somatic recombination

• Clonal expansion

• Receptor editing

• Imprecise recombination junction

 Which statement is TRUE about the adaptive immune response/clonal expansion?

• Each B cell bears a receptor that will be specific for a particular antigen, and it may have many identical copies of that receptor

• Interactions between a foreign molecule and a lymphocyte receptor capable of binding that molecule with high affinity leads to lymphocyte activation

• The differentiated effector cells derived from an activated lymphocyte will bear receptors of identical specificity to those of the parental cell from which that lymphocyte was derived

• Lymphocytes bearing receptors specific for ubiquitous self molecules are deleted at an early stage in lymphoid cell development and are therefore absent from the repertoire of mature lymphocytes

• All are true

Tags

NGSS.HS-LS1-4

Which of the following pair is MISMATCHED?

• Neutrophils: most abundant leukocytes

• Natural killer (NK) cells: kill virus-infected cells via phagocytosis

• Macrophage: phagocytosis and killing of microorganisms

• Monocytes: precursor cell to macrophage

• Mast cells: release histamine

Which of the following statements about antibodies is false?

• 1. Each antibody has two identical heavy chains and two identical light chains

• In contrast to BCR, an antibody does not have transmembrane region

• 1. Each light chain is composed of two variable regions 

• Each heavy chain is composed of variable region and constant region

Which of the following statements regarding immunoglobulins is correct?

• 1. Immunoglobulins make up five classes (or isotypes) called IgA, IgD, IgE, IgG, and IgM.

• Regardless of their isotype, immunoglobulins all have the same effector function.

• Antibodies consists of four identical heavy chains and four identical light chains

• The constant regions make up the antigen  binding site

• None of the above

Which of the following complement components is an opsonin that binds to complement receptor 1 (CR1) on macrophages?

• C3b

• C3a

• Bb

• Ba

• C3bBb

Which of these genetic defects would result in a lack of somatic recombination between V, D, and J segments?

• lack of a functional activation-induced cytidine deaminase gene

• lack of a functional RAG1 gene

• lack of a functional terminal deoxynucleotidyl transferase gene

• • lack of a functional exonuclease

Primary lymphoid tissues are the sites where lymphocytes __________, whereas secondary lymphoid tissues are the sites where lymphocytes __________.

• are stimulated; develop and mature

• encounter pathogens; undergo apoptosis

• develop and mature; become stimulated

• die; are phagocytosed after death.