Cancer Biology_CH5_MAPK_3377_2024

The role of MEK in the MAPK pathway is to:

• Phosphorylate receptor tyrosine kinases

• Phosphorylate ERK

• Activate RAS

• Degrade proteins

The role of MAPK in the MAPK pathway is to:

• Activate the transcription of certain genes necessary for cell cycle progression and proliferation.

• Decrease the expression of proteins involved in DNA repair

• Inhibit the production of proteins involved in cell survival and growth.

• Suppress the immune system's response to pathogens

_________ is downstream of MEK in the MAPK pathway.

• ERK

• RAS

• RAF

• GTP

The role of RAF in the MAPK pathway is to:

• Phosphorylate ERK

• Inhibit RAS

• Activate MEK

• Activate transcription factors

Which growth factor typically activates the MAPK pathway?

• Epidermal growth factor (EGF)

• Insulin-like growth factor (IGF)

• Transforming growth factor-beta (TGF-β)

• Platelet-derived growth factor (PDGF)

This protein is responsible for activating RAS in the MAPK pathway.

• Grb2

• Sos

• MEK

• ERK

The MAPK pathway is involved in the regulation of cell proliferation, differentiation, and survival.

• True

• False

MAPK is directly activated by binding to receptor tyrosine kinases.

• True

• False

MAPK exclusively acts in the cytoplasm and does not translocate to the nucleus.

• True

• False

What is dimerization in the context of receptor tyrosine kinase (RTK) activation?