PK Board Review 2024

A 79-year old man is hospitalized after falling from a cliff. His current medical problems include cardiogenic shock, heart failure,renal disease and cirrhosis from chronic alcoholism. Due to weight loss, he is felt to be somewhat hypermetabolic. Which of the following factors will have the most significant effect to decrease drug-half life of medications administered to him?

• Cardiogenic shock

• Heart failure

• Cirrhosis

• Hypermetabolic state

A 5 mg dose of a drug is administered to a patient and then the plasma concentration of the drug is determined as 0.15 mcg/mL. What is the volume of distribution of the drug in this patient?

• 1500 mL
• 33 L

• 1.5 L

• 5000 mL

A patient is receiving 0.4 g gentamycin IV once daily. The AUC was determined to be 95 mg x hr/L. Calculate the patient's gentamycin clearance.

• 5.82 L/hr

• 4.21 L/hr

• 2.11 L/hr

• 3.5 L/hr

In a pharmacokinetic study of an IV bolus dose of 20 mg the AUC was determined to be 5 mg x hr/L. Later given an oral dose of 50 mg and the AUC was determined to be 7.5 mg x hr/L. Calculate the absolute bioavailability of the investigational drug.

• 60%

• 12%

• 80%

• 30%

Calculate an oral loading dose of digoxin to achieve a peak plasma concentration of 2 mcg/L (F = 0.65; Vd = 450 L).

• 1000 mcg
• 2000 mcg
• 500 mcg
• 1385 mcg

A patient received an IV dose of gentamycin. It was determined that the drug level was 8 mg/L, and the patient's Ke = 0.14/h. Calculate the predicted concentration after 12 h.

• 0.74 mg/L

• 1.48 mg/L

• 4.20 mg/L

• 0.17 mg/L