Intra or extra

Disturbance of hgb synthesis includes

• iron deficiency anemia

• Thalassemia

• Thalassemia and iron deficiency anemia

• Iron deficiency anemia and sideroblastic anemia

Unknown or multiple mechanisms

• Thalassemia, chronic renal failure, anemia of endocrine disorders

• Megaloblastic anemia

• Chronic disease, sideroblastic anemia

• Hereditary spherocytosis

Disturbance of proliferation and differentiation of precursor erythroid cells:

• Anemia of chronic renal failure, anemia of endocrine disorders

• Aplastic anemia

• Chronic diseases, sideroblastic anemia

• Iron deficiency anemia, Thalassemia

Intracorpuscular or extracorpuscular?: Membrane defects: Hereditary spherocytosis, hereditary elliptocytosis, hereditary pyropoikolyocytis

• Intra

• Extra

Intracorpuscular or extracorpuscular?: Mechanical: Hemolytic anemia

• Intra

• Extra

Intracorpuscular or extracorpuscular?: Infection: Hemolytic anemia secondary to infection with malaria, babesia, Bartonella, Ehrlichia

• Intra

• Extra

Intracorpuscular or extracorpuscular?: Antibody meditated: Hemolytic anemia

• Intra

• Extra

Intracorpuscular or extracorpuscular?: Enzyme deficiency: G6PD deficiency, pyruvate kinase, porphyria

• Intra

• Extra

Globin abnormalities: Hemoglobinopathies Intracorpuscular or extracorpuscular?:

• Intra

• Extra

Intracorpuscular or extracorpuscular?: Paroxysmal nocturnal hemoglobinuria

• Intra

• Extra