Cancer and the Cell Cycle

Which below is true of the normal cell cycle? MARK ALL THAT APPLY.

• The S phase takes place after the G2 phase.

• The G1 phase is the point when organelles duplicate.

• The order of the cell cycle is: G1, S, G2, then M, and occassionally the G0 phase

• There are 5 checkpoints in the normal cell cycle.

Which 2 enzyme types are responsible for each checkpoint during the cell cycle?

• CDK (cyclin dependent kinase) and cyclins

• CDK and tetracyclines

• CPR's and cyclins

• p53 and CDK

Tags

NGSS.HS-LS1-4

Genetic mutations cause faulty checkpoint activity in normal cells thus causing them to transform. Which type of mutation below discussed in lecture best describes Epigenetic modification?

• chromosomal rearrangement

• DNA is overly amplified or not amplified enough (down regulated).

• a point mutation

• Changes to the DNA, which regulates gene expression, but have no affect on the nucleotide sequence. Includes methylation.

Tags

NGSS.HS-LS3-2

Cancer cells do not pass cell cycle checkpoints, and so they undergo apoptosis and die.

• True

• False

What is a term for programmed cell death?

• apoptosis
• necrosis
• cell death
• doom

In the S stage of interphase....

• The cell grows
• The nucleus divides
• The cell membrane divides
• The DNA is replicated

Which molecules act as gatekeepers for each checkpoint of the cell cycle?

• p53 gene

• cyclins and cycline-dependent kinases

• thyroid hormones

What is the purpose the the cell cycle checkpoints?

• To repair damaged cells before they enter cell division.

• To remove damaged cells from an organism.

Tags

NGSS.HS-LS1-4

How many cell cycle checkpoints are there?

• 1

• 2

• 3

• 4

What is the first checkpoint of the cell cycle?

• Mitosis checkpoint

• G₁ checkpoint

• G₂ checkpoint