Sacu + Val

Mechanism of action of Sacubitril is that it blocks the breakdown of ___________ produced in the body

• Angiotensin II

• Aldosterone

• Natriuretic peptides

• None of these

Mechanism of action of Valsartan is that it blocks _____receptors to prevent action of Angiotensin II

• AT2

• AT1

• Alpha 1

• Alpha 2

Heart failure with Preserved Ejection Fraction is due to

• Ineffective Filling

• Due to diastolic heart failure

• Both 1 & 2

• None of these

Heart failure with Reduced Ejection Fraction is due to

• Ineffective pumping by Left Ventricle

• Due to systolic failure

• Both 1 & 2

• None of these

State True or False: Raised Jugular Vein Pressure (JVP) is a sign of Heart Failure

• True

• False

As per AHA/ACC/HFSA 2022 guidelines in the management of Heart Failure in patients with HFrEF of NYHA class II & III, ARNI is recommended as Class _____recommendation

• 1A

• 1C

• Iia

• Iib

Recommended starting dose of Sacubitril & Valsartan in HFrEF in normal kidney & Liver function is ____mg twice daily which can be uptitrated to _____mg twice daily at an interval of 2 to 4 weeks.

• 50, 100

• 100, 200

• 25, 50

• 25, 100

Combination of Sacubitril and Valsartan in HF TRIL 200 mg has 

• Sacubitril 95 mg & Valsartan 105 mg

• Sacubitril 97 mg & Valsartan 103 mg

• Sacubitril 92 mg & Valsartan 108 mg

• Sacubitril 90 mg & Valsartan 110 mg

Stoichiometric form of Hftril similar to innovator leads to 

• Reduced hygroscopicity

• Stability across different temperature conditions

• Improved bioavailability

• All of these

For patient empowerment, Hftril comes in ______days compliance pack

• 7

• 10

• 14

• 30