Quiz on Cancer Genomics

What is the general process of cancer formation called?

• Carcinogenesis

• Hyperplasia

• Dysplasia

• Tumorigenesis

Which term refers to an abnormal new growth of cells?

• Tumor

• Neoplasm

• Dysplasia

• Hyperplasia

What type of cancer genes cannot be passed on to subsequent generations?

• Germline cancer genes

• Somatic cancer genes

• Oncogenes

• Tumor suppressor genes

What percentage of cancers arise sporadically?

• 50-60%

• 70-80%

• 90-95%

• 99-100%

What is a proto-oncogene?

• A normal gene with the potential to become an oncogene

• A mutated tumor suppressor gene

• A type of germline cancer gene

• A hypermethylated gene

What is the role of tumor suppressor genes?

• Promote cell proliferation

• Prevent uncontrolled cell growth

• Increase mutational signatures

• Stimulate chromothripsis

What process leads to the silencing of hypermethylated promoters?

• Gene duplication

• Genome instability

• Hypermethylation

• Chromothripsis

What type of mutations are referred to as 'driver mutations'?

• Random mutations

• Mutations that provide a selective growth advantage

• Passenger mutations

• Germline mutations

Which mutagen is associated with UV-B exposure?

• Polycyclic aromatic hydrocarbons

• Chromothripsis

• Cyclobutane dimers

• Kataegis

What is the primary source of aneuploidies in cancer cells?

• Defects in the spindle checkpoint

• Kataegis

• Hypermethylation

• Genome instability