HLA Antibodies and Transplantation
Authored by rasha mamdouh
Other
University
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9 questions
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1.
OPEN ENDED QUESTION
3 mins • 1 pt
What are donor specific antibodies?
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2.
MULTIPLE SELECT QUESTION
30 sec • 1 pt
What are the advantages of CDC in DSA detection?
Functional assay
Detects complement fixing antibodies
3.
MULTIPLE SELECT QUESTION
30 sec • 1 pt
What are the limitations of CDC in DSA detection?
Low sensitivity and specificity
Detects both IgG and IgM
Needs experience in interpretation
Detects HLA and non HLA/autoantibodies
4.
MULTIPLE SELECT QUESTION
30 sec • 1 pt
What are the advantages of DSA detection by Luminex?
Highly sensitive
Determine HLA specificities
Detects IgG antibodies only
5.
MULTIPLE SELECT QUESTION
30 sec • 1 pt
What are the limitations of DSA detection by Luminex?
False-positive reactions
Complement and IgM interference
MFI values do not translate directly into the antibody level
6.
OPEN ENDED QUESTION
3 mins • 1 pt
What is the significance of DSA presence?
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7.
OPEN ENDED QUESTION
3 mins • 1 pt
What is the mechanism of graft failure?
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