Chemotherapeutic Agents

Nitrosoureas are alkylating agents that are

• water-soluble

• lipid soluble

• stable compounds

• Non-reactive

The half life of nitrosoureas are

• 2-3 hours

• 4-6 hours

• 5-15 minutes

• 20-25 minutes

Folic acid is converted into tetrahydrofolate by an enzyme known as

• CYP450

• Tetrahydrofolate reductase

• dihydrofolate reductase

• Hydrolase reductase

Anti-metabolites are structurally related to

• naturally occurring vitamins

• naturally occurring enzymes

• naturally occurring hormones

• naturally occurring minerals

Mercaptopurine is an analog of

• uracil

• purine

• hypoxanthine

• adeninine