AP Biology Mutations

In what way might a point mutation in DNA make a difference in the function of a protein?

• It might substitute the N-terminus of the polypeptide for the C-terminus.

• It might exchange one stop codon for another stop codon.

• It might substitute a different amino acid in the active site.

• It might result in a chromosomal translocation.

• It might exchange one serine codon for a different serine codon

Tags

NGSS.HS-LS1-1

NGSS.HS-LS3-2

Which of the following DNA mutations is likely to have the most negative effect on the protein it specifies?

• a codon substitution

• a base-pair deletion

• a codon deletion

• a substitution in the last base of a codon

Tags

NGSS.HS-LS3-2

Which of the following types of mutations could result in a frameshift mutation?

• deletion of three consecutive bases

• a base deletion only

• a base insertion only

• either an insertion or a deletion of a base

• a base substitution only

Tags

NGSS.HS-LS3-2

What is the effect of a nucleotide-pair substitution that results in a nonsense mutation in a gene?

• It has no effect on the amino acid sequence of the encoded protein.

• It alters the reading frame of the mRNA.

• It introduces a premature stop codon into the mRNA.

• It changes an amino acid in the encoded protein.

Tags

NGSS.HS-LS1-1

NGSS.HS-LS3-2

When a mutation caused by a nucleotide pair insertion occurs in a protein coding region, which of the following effects can not occur?

• silent

• frameshift

• missense

• nonsense

• All are possible.

Tags

NGSS.HS-LS3-2

True or False: All mutations are negative.

• True

• False

Tags

NGSS.HS-LS3-2

NGSS.HS-LS4-1

NGSS.HS-LS4-2

Which of the following is the best example of gene expression?

• A frog adapts to variation in its environmental temperature.

• Mouse fur color results from pigment formed by gene-encoded enzymes.

• DNA is replicated during the S phase of the cell cycle.

• The percent of A versus a alleles in a population is altered by natural selection.

• Mutation alters the sequence of a region of DNA.

Tags

NGSS.HS-LS1-6

Which type of mutation involves the replacement of one nucleotide and its partner with another pair of nucleotides?

• Silent mutation

• Missense mutation

• Nonsense mutation

• Base-pair substitution

Tags

NGSS.HS-LS3-2

What is the consequence of a frameshift mutation in a gene?

• It results in a protein with a different amino acid sequence.

• It introduces a premature stop codon.

• It has no effect on the protein.

• It only affects the first amino acid.

Tags

NGSS.HS-LS1-1

Which of the following mutations is least likely to affect protein function?

• Nonsense mutation

• Missense mutation

• Silent mutation

• Frameshift mutation

Tags

NGSS.HS-LS1-1

NGSS.HS-LS3-2