Principles of Topical Therapy (183) & Antihistamines (189)

Which of the following is the primary compartment that limits percutaneous absorption of compounds? 

• stratum basale

• stratum corneum

• stratum granulosum

• stratum spinosum

Answer explanation

page 3367

A patient consulted because of tinea corporis on the abdomen and thighs measuring 10% body surface area. How many grams of terbinafine should the patient apply?

• 1

• 1.5

• 2

• 2.5

Answer explanation

1 FTU (equivalent to 500mg) covers 2% BSA

Which topical formulation is ideal for use in facial or hair bearing areas but may cause drying or stinging?

• gels

• hydrocarbon bases

• pastes

• water-in-oil emulsions

Answer explanation

Table 183-4 (page 3373)

Which is considered as an emollient?

• emulsifying wax

• petrolatum

• propylene glycol

• sorbitol

Answer explanation

page 3372

emulsifying wax = emulsifying agent

propylene glycol = stabilizer, solvent, humectant

sorbitol = humectant

Powders are ideal for which area of the body?

• hair-bearing areas

• intertriginous area

• palms

• abdomen

Answer explanation

page 3373, table 183-4

Which medication with strong H1 and H2 blockade?

• Cimetidine

• Cyproheptadine

• Doxepin

• Fexofenadine

Answer explanation

page 3459

Which of the following is a metabolite of hydroxyzine?

• cetirizine

• ebastine

• fexofenadine

• loratadine

Answer explanation

page 3541

Which of the following is metabolised in the liver via the hepatic CYP3A4?

• cetirizine

• fexofenadine

• levocetirizine

• loratadine

Answer explanation

page 3453

Which of the following is a contraindication for antihistamine therapy?

• Cataract

• Herpetic keratitis

• Narrow-angle glaucoma

• Uveitis

Answer explanation

page 3455, Table 189-4

A patient on dialysis poses the risk of toxicity with which of the following antihistamines?

• chlorpheniramine

• diphenhydramine

• ebastine

• mizolastine

Answer explanation

page 3454, Table 189-3; All other choices require dose adjustment for patients with hepatic impairment