Quiz about Exam 2 Advanced Hematology

Question 1

How many blast cells in a bone marrow aspirate smear are necessary for a diagnosis of acute myeloid leukemia using the WHO criteria?

Accepted Answer

20%

Answer

15%

Answer

25%

Answer

30%

Question 2

What cytochemical stain is best for differentiating AML from ALL?

Accepted Answer

Myeoperoxidase

Answer

Alpha-napthyl acetate

Answer

Nonspecific esterase

Answer

Periodic acid Schiff

Question 3

Which peripheral blood morphology is associated with dysmyelopoieisis?

Accepted Answer

Hyposegmentation

Answer

Hypogranulation

Answer

Schistocytes

Answer

Presence of Heinz Bodies

Question 4

Which Leukemia is more common in Children?

Accepted Answer

Acute Lymphoblastic leukemia

Answer

Acute myelomonocytic leukemia

Answer

Acute Myelogenous leukemia

Answer

Acute myeloid leukemia with minimal maturation

Question 5

Which chromosome abnormality is associated with mantle cell lymphoma?

Accepted Answer

t(11;14)

Answer

t(16;16)

Answer

t(14;18)

Answer

Trisomy 8

Question 6

Which of the following pairs of cytochemical stains provide essentially the same information with regard to blast cell identity in acute leukemia cases?

Accepted Answer

chloroacetate esterase and Sudan Black B

Answer

acid phosphatase and myeloperoxidase

Answer

Periodic acid-Schiff and alkaline phosphatase

Answer

alpha napthyl acetate esterase and myeloperoxidase

Question 7

Which of the following is a key marker for Chronic Lymphocytic Leukemia (CLL)?

Accepted Answer

CD5+ and CD23+

Answer

CD10+ and BCL2+

Answer

CD19+ and CD20-

Answer

CD15+ and CD30+

Question 8

Which lymphoma subtype is characterized by Reed-Sternberg cells?

Accepted Answer

Hodgkin Lymphoma

Answer

Diffuse Large B-Cell Lymphoma

Answer

Follicular Lymphoma

Answer

Burkitt Lymphoma

Question 9

Which B-cell neoplasm is associated with an aggressive clinical course and CD10 positivity?

Accepted Answer

Burkitt Lymphoma

Answer

Chronic Lymphocytic Leukemia

Answer

Plasma Cell Myeloma

Answer

Mycosis Fungoides

Question 10

Which of the following phenotypes is characteristic of hairy cell leukemia?

Accepted Answer

CD11c+, CD19+, CD103+

Answer

CD3+, CD4+, CD7+

Answer

CD11c+, CD3+, CD10+

Answer

CD13+, CD19+, CD25+

Question 11

Polycythemia vera can be differentiated from secondary polycythemia by measuring:

Accepted Answer

erythropoeitin

Answer

hematocrit

Answer

plasma volume

Answer

hemoglobin

Question 12

Which of the following is a hallmark finding in Myelodysplastic Syndromes (MDS)?

Accepted Answer

Ineffective hematopoiesis and increased apoptosis

Answer

Presence of Reed-Sternberg cells

Answer

Presence of Auer rods in peripheral blood

Answer

t(9;22) translocation

Question 13

Which immunophenotypic marker is most characteristic of B-cell Acute Lymphoblastic Leukemia (B-ALL)?

Accepted Answer

CD34+, CD19+, TdT+

Answer

CD3+, CD4+, CD8+

Answer

CD33+, MPO+

Answer

CD15+, CD30+

Question 14

The presence of Auer rods is a defining feature of which leukemia subtype?

Accepted Answer

AML

Answer

ALL

Answer

CLL

Answer

MDS

Question 15

Which cytogenetic abnormality is associated with a poor prognosis in Acute Lymphoblastic Leukemia (ALL)?

Accepted Answer

t(9;22)(q34;q11)

Answer

t(12;21)(p13;q22)

Answer

inv(16)(p13;q22)

Answer

t(8;21)(q22;q22)

Question 16

Which genetic mutation is most commonly associated with Polycythemia Vera (PV)?

Accepted Answer

JAK2 V617F

Answer

BCR-ABL1

Answer

CALR mutation

Answer

MPL mutation

Question 17

Chronic Myeloid Leukemia (CML) is characterized by which chromosomal translocation?

Accepted Answer

t(9;22)(q34;q11)

Answer

t(15;17)(q24;q21)

Answer

t(11;14)(q13;q32)

Answer

t(8;14)(q24;q32)

Question 18

Which of the following poikilocytes is a characteristic finding in primary myelofibrosis (PM)?

Accepted Answer

teardrop cell

Answer

schistocyte

Answer

spherocyte

Answer

target cell

Question 19

In which category does Refractory Anemia (RA) fall according to the WHO classification of Myelodysplastic Syndromes (MDS)?

Accepted Answer

MDS with single lineage dysplasia (MDS-SLD)

Answer

MDS with excess blasts (MDS-EB)

Answer

MDS with multilineage dysplasia (MDS-MLD)

Answer

MDS with isolated del(5q)

Question 20

Which of the following best describes the bone marrow findings in Refractory Anemia (RA)?

Accepted Answer

Dysplasia limited to the erythroid lineage with <5% blasts

Answer

Dysplasia affecting multiple cell lineages

Answer

Presence of >5% blasts in the bone marrow

Answer

Increased megakaryocytes with abnormal morphology

Question 21

What is the blast percentage cutoff in the peripheral blood for diagnosing Refractory Anemia (RA)?

Accepted Answer

<1%

Answer

5-10%

Answer

10-20%

Answer

>20%

Question 22

Which of the following is NOT a typical characteristic of Refractory Anemia (RA)?

Accepted Answer

Ringed sideroblasts present in all cases

Answer

Anemia as the primary cytopenia

Answer

No Auer rods in peripheral blood or bone marrow

Answer

Low risk of progression to acute leukemia

Question 23

Which chromosomal translocation is most commonly associated with Acute Promyelocytic Leukemia (APL)?

Accepted Answer

t(15;17)

Answer

t(8;21)

Answer

t(9;22)

Answer

t(11;14)

Question 24

Which immunophenotypic marker is most characteristic of B-cell Acute Lymphoblastic Leukemia (B-ALL)?

Accepted Answer

CD34+, CD19+, TdT+

Answer

CD3+, CD4+, CD8+

Answer

CD33+, MPO+

Answer

CD15+, CD30+

Question 25

What is the genetic alteration for Chronic Eosinophilic leukemia?

Accepted Answer

Trisomy 8

Answer

BCR/ABL1

Answer

JAK2

Answer

CSFR3r

Question 26

What is the genetic alteration for PMF

Accepted Answer

JAK2

Accepted Answer

CALR

Accepted Answer

MPL

Answer

BCR/ABL1

Question 27

Which genetic mutation is most commonly associated with Polycythemia Vera (PV)?

Accepted Answer

JAK2 V617F

Answer

BCR-ABL1

Answer

CALR mutation

Answer

MPL mutation

Question 28

The key characteristic for distinguishing between myelodysplastic syndrome and acute leukemia is:

Accepted Answer

percent of bone marrow blasts

Accepted Answer

bone marrow cellularity

Answer

Plasma cell infiltrate

Answer

None of these

Question 29

Which chromosome abnormality is specifically associated with myelodysplastic syndrome?

Accepted Answer

deletion of long arm of chromosome 5

Answer

translocation between chromosomes 17 and 22

Answer

loss of the Y chromosome

Answer

addition of chromosome 7

Question 30

Which chromosome abnormality gives rise to the hybrid gene, MYC/IGH?

Accepted Answer

t(8;14)

Answer

t(8;21)

Answer

t(9;22)

Answer

t(15;17)

Question 31

The cytochemical stain, chloroacetate (specific) esterase is useful for identifying blast cells of:

Accepted Answer

myeloid lineage

Answer

lymphoid lineage

Answer

monocytic lineage

Answer

erythroid lineage

Question 32

Which genetic abnormality gives rise to the hybrid gene CBFB/SMMHC

Accepted Answer

t(16;16)

Answer

t(12;21)

Answer

t(8;21)

Answer

t(9;11)

Question 33

Malignancies associated with which genetic mutation can be successfully treated with Gleevec?

Accepted Answer

BCR/ABL

Answer

JAK2(V617F)

Answer

RAR/PML

Answer

FRK(K423W)

Question 34

Which laboratory tests would help distinguish myelodysplastic syndrome from megaloblastic anemia?

Accepted Answer

serum folate and vitamin B12

Answer

reticulocyte count

Answer

myeloperoxidase stain

Answer

lactate dehydrogenase

Question 35

What cytochemical stain is used to help differentiate a leukemoid reaction from CML?

Accepted Answer

Leukocyte Alkaline Phosphatase

Answer

Myeloperoxidase

Answer

New Methylene Blue

Answer

Perl's Prussian Blue

Question 36

Which of the following markers is expressed in most cases of AML?

Accepted Answer

CD117

Answer

CD2

Answer

CD10

Answer

CD11b

Question 37

What is the typical M:E ratio in patients with CML (chronic myelogenous leukemia)? Select the best answer.

Accepted Answer

15:1

Answer

1:10

Answer

1:5

Answer

3:1

Question 38

Which of the following is consistent with leukemoid reaction?

Accepted Answer

High LAP

Answer

Low WBC Count

Answer

Basophilia

Answer

Presence of ph chromosome

Question 39

Which phase of CML carries the worst prognosis and is generally unresponsive to treatment?

Accepted Answer

Blastic

Answer

Chronic

Answer

Accelerated

Answer

Refractory

Question 40

Which of the following myeloproliferative disorders is characterized by a decreased LAP score?

Accepted Answer

CML

Answer

PMF

Answer

ET

Answer

PV

Question 41

Review the attachment and answer the following question:

What is the probable diagnosis based on the result?

Accepted Answer

CML

Answer

ALL

Answer

CLL

Answer

AML

Question 42

Review the attachment and answer the following question:

Which lab result is most helpful in obtaining a diagnosis?

Accepted Answer

The identification of the BCR/ABL1 is most helpful in offering a diagnosis.

Answer

The identification of the Myeoblast is most helpful in offering a diagnosis.

Answer

PLT Count of 70

Answer

None of the choices listed

Exam 2 Advanced Hematology

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