HO OSP 18

Ps with megaloblastic anemia (deficiency B12 and folic acid).

In Peripheral Blood Smear we can find:

• Macrocytic with neutropenia

• Macrocytic with neutrophilia

• Macrocytic with toxic granulation neutrophil

• Macrocytic with hyper segmentation neutrophil

• Macrocytic with hypo segmentation neutrophil

Mr Rendy came to Internal Department with complain abdominal discomfort.

Physical examination: splenomegaly. CBC: Increase Immature myeloid. Bone

marrow: increase of reticulin fiber and collagen tissue.

According to this result what kind of cell do you expect will be find in

peripheral blood smear. We find cell…

• Target cell

• Pencil cell

• Teardrop cell

• Macrocyte

We can find many cell like this in:

• Anemia deficiency Fe

• Anemia deficiency B12

• Anemia in Chronic Kidney Disease

• Anemia Deficiency Folat

• Anemia chronic disease

Test for assess capillary fragility

• Activate partial thromboplastin time (aPTT)

• Platelet count

• Rumpel-Leede test

• Prothrombin time

• Bleeding time

Roy 4 years old male, came with his parent to Hematologist. His parent told

since 3 years ago his boy look pale and weakness. In physical examination:

Pale. Laboratory examination:

Hb 9,5 gr/dL

Hemoglobin Electrophoresis:

Hb A: 92 % (N: 98%)

Hb A2 : 5% (N: 1 – 2%)

Hb F: 3 % (N: < 1 %)

In peripheral blood smear physician can find many

……… cell

• Pencil cell

• Target cell

• Macrocyte

• Teardrop cell

Toni 8 years old male, came with his parent to Hematologist. His parent told

since 1 years ago his boy look pale and weakness. In physical examination:

Pale. Laboratory examination:

Hb 9,5 gr/dL, WBC, Platelet: Normal, MCV: 65 fL (N: 80 -100 fL)

Specific cells Ps with anemia hemolytic:

• Target cells

• Macrocyte

• Pencil cell

• Fragmentocyte

• Tear drop cells

We can find many cell like this in:

• Anemia chronic disease

• Anemia deficiency folat

• Anemia in Chronic Kidney Disease

• Beta thalassemia mayor

• Anemia deficiency B12

Toni 8 years old male, came with his parent to Hematologist. His parent told

since 1 years ago his boy look pale and weakness. In physical examination:

Pale. Laboratory examination:

Hb 9,5 gr/dL, WBC, Platelet: Normal, MCV: 65 fL (N: 80 -100 fL)

To supporting diagnosis, what kind examination do you need?

• Folic acid serum

• Bone marrow examination

• Albumin serum

•  B12 Serum

• Serum iron and total iron binding capacity

A 59-year old male has enlarged lymph nodes in colli lateral sinistra along

with weight loss. No abnormal condition resulted in a peripheral blood smear

examination and bone marrow biopsy. The biopsy results from one of the

lymph nodes could be seen in this microscope. What is the specific cell in

such diseases?

• Kikuchi cell

• Reed Sternberg cell

• Touton’s cell

• Frank’s cell

• Langhan’s cell

 Toni 8 years old male, came with his parent to Hematologist. His parent told

since 1 years ago his boy look pale and weakness. In physical examination:

Pale. Laboratory examination:

Hb 9,5 gr/dL, WBC, Platelet: Normal, MCV: 65 fL (N: 80 -100 fL)

In peripheral blood smear physician can find specific cell (specific form of Toni’s

RBC): ………. Cell

• Tear drop cell

• Target cell

• Pencil cell

• Macrocyte