thalassemia update

What type of inheritance is Thalassemia

• Autosomal dominant

• Autosomal recessive

• Xlinked dominant

• Xlinked recessive

List two sets of lab data that can distinguish IDA from beta thalassemia trait.

• Serum iron and RBC

• Hgb and Hct

• WBC and RDW

• RBC indices and Platelets

What is the majority hemoglobin in beta thalassemia major

• Hgb A

• Hgb A2

• Hgb F

• Hgb H

Which of the following alpha thalassemia is inconsistent with life?

• Alpha thal trait

• Alpha thal minor

• Hgb H

• Hgb Bart's

Which of the following hemoglobins contains γ₄ tetramers?

• Hgb Bart's

• Hgb Gower

• Hgb H

• Hgb Portland

What disease does the following code for: β⁺ β

• beta thal minor

• beta thal intermedia

• beta thal major

• Cooley's anemia

What disease does the following code for: αα/- -

• Aphal thal trait

• Alpha thal minor

• Hgb H

• Hgb Bart's

What is sign & symptoms of Thalassemia

• easily tired

• pallor

• hepatosplenomegaly

• easily bruising

Cut of point of MCH & MCV for thalassemia screening

• MCH<30

  MCV <80

• MCH<27

  MCV<80

• MCH<25

  MCV<75

• MCH>25

  MCV>75

When do we start iron chelator?

• Start iron chelator when there is evidence of iron overload.
• Start iron chelator for all patients regardless of iron levels.
• Start iron chelator after a blood transfusion.
• Start iron chelator when there is low hemoglobin.