Approach to Hemolytic Anemia Quiz

Investigation of choice for Paroxysmal Nocturnal Hemoglobinuria?

• Ham test

• Flow cytometry

• Acidified glycerol test

• Acidified serum test

Most probable diagnosis is?

• Thalassemia major

• Thalassemia minor

• Sickle cell anemia

• Immune hemolytic anemia

Hb Barts is composed of:

• Four γ chains

• Four β chains

• Four alpha chains

• Four ε chains

Identify the peripheral smear picture.

• Sickle cell anemia

• Beta Thalassemia minor

• Microangiopathic hemolytic anemia

• HbH disease

Autosplenectomy is seen in

• Hereditary spherocytosis

• Immune hemolytic anemia

• Thalassemia

• Sickle cell anemia

Most common mutation in Hereditary spherocytosis

• Spectrin

• Ankyrin

• Band 3

• Band 4.2

Intravascular hemolysis is predominant in

• Hereditary spherocytosis

• Thalassemia

• Hereditary elliptocytosis

• Hemolytic uremic syndrome

Features of hemolytic anemia are all except:

• Increased bilirubin

• Increased reticulocytes

• Increased urobilinogen

• Increased haptoglobin

Investigation of choice for Thalassemia?

• Ham test

• Bone marrow Aspiration

• Hemoglobin electrophoresis

• Acidified serum test

During Hematology class, Arnav learnt about G6PD deficiency and its effects on red blood cells. His facilitator mentioned various aspects of this condition. Which of the following statements about G6PD deficiency is false?

• Episodic hemolysis

• Young RBCs are more prone to hemolysis

• Both intra & extravascular hemolysis

• X linked recessive