Structure & Biosynthesis of Collagen

What is the most abundant type of collagen found in the human body?

• A. Type II

• B. Type III

• C. Type IV

• D. Type I

Which cells are primarily responsible for the synthesis of collagen in connective tissue?

• A. Osteoblasts

• B. Fibroblasts

• C. Chondrocytes

• D. Hepatocytes

Collagen synthesis begins in which cellular organelle?

• A. Mitochondria

• B. Golgi apparatus

• C. Rough endoplasmic reticulum

• D. Nucleus

Which vitamin is essential for hydroxylation of proline and lysine residues during collagen synthesis?

• A. Vitamin A

• B. Vitamin D

• C. Vitamin C

• D. Vitamin K

The triple helical structure of collagen is stabilized by which type of bond?

• A. Hydrogen bonds

• B. Ionic bonds

• C. Disulfide bonds

• D. Covalent bonds

What is the name of the precursor molecule of collagen synthesized inside the cell?

• A. Tropocollagen

• B. Procollagen

• C. Pre-collagen

• D. Hydroxy collagen

Hydroxylation of proline and lysine requires all of the following EXCEPT:

• A. Fe²⁺

• B. Oxygen

• C. Vitamin C

• D. Biotin

The enzyme responsible for hydroxylation of proline in collagen synthesis is:

• A. Lysyl oxidase

• B. Prolyl hydroxylase

• C. Collagenase

• D. Peptidyl transferase

Cross-linking of collagen fibers in the extracellular matrix is catalyzed by:

• A. Collagenase

• B. Prolyl hydroxylase

• C. Lysyl oxidase

• D. Peptidase

Which trace element is required for lysyl oxidase activity in collagen maturation?

• A. Iron

• B. Copper

• C. Zinc

• D. Magnesium