Advantages of HPLC Over GC

What does HPLC stand for?

• High-Pressure Liquid Chromatography

• High-Performance Liquid Composition

• High-Precision Liquid Chromatography

• High-Performance Liquid Chromatography

What does GC stand for?

• Geothermal Circulation

• Gas Chromatography

• General Chemistry

• Gas Compression

Name one advantage of HPLC related to sample types.

• HPLC requires samples to be in a specific format.

• HPLC cannot analyze complex mixtures.

• HPLC is limited to liquid samples only.

• HPLC can handle diverse sample types effectively.

How does HPLC handle thermally unstable compounds?

• HPLC requires high temperatures to analyze thermally unstable compounds.

• HPLC uses only standard equipment without modifications for unstable compounds.

• HPLC eliminates the need for temperature control when analyzing unstable compounds.

• HPLC uses low-temperature conditions and specialized equipment to analyze thermally unstable compounds.

Why is HPLC preferred for polar compounds?

• HPLC cannot separate polar compounds at all.

• HPLC is only effective for non-polar compounds.

• HPLC is preferred for polar compounds due to its ability to effectively separate and analyze them using polar stationary and mobile phases.

• HPLC is less efficient for polar compounds than gas chromatography.

What is one advantage of HPLC in terms of separation speed?

• HPLC is slower than traditional methods.

• HPLC provides faster separation of compounds compared to traditional methods.

• HPLC cannot separate compounds effectively.

• HPLC requires more sample preparation time.

How does HPLC compare to GC in terms of sensitivity?

• HPLC and GC have the same sensitivity.

• HPLC is typically more sensitive than GC.

• HPLC is less sensitive than GC.

• GC is more sensitive than HPLC.

What type of detectors are commonly used in HPLC?

• Common detectors used in HPLC include UV-Vis detectors, fluorescence detectors, and refractive index detectors.

• Electrochemical detectors

• Mass spectrometry detectors

• Thermal conductivity detectors

Can HPLC analyze larger molecules compared to GC?

• No, GC can analyze larger molecules than HPLC.

• Both HPLC and GC can only analyze small molecules.

• HPLC is not suitable for any type of molecule analysis.

• Yes, HPLC can analyze larger molecules compared to GC.

What is one reason HPLC is used in pharmaceutical analysis?

• It allows for precise separation and quantification of compounds.

• It requires no sample preparation before testing.

• It is only used for solid samples.

• It is the fastest method for all types of analysis.