NUTRIGENOMICS & DIABETES

Which of the following PPARG genotypes is associated with reduced risk of type 2 diabetes?

• A. Pro/Pro

• B. Pro/Ala

• C. Ala/Ala

• D. Both B and C

TCF7L2 is involved in which of the following pathways that influence diabetes risk?

• A. mTOR signaling

• B. Wnt signaling

• C. JAK/STAT pathway

• D. AMPK signaling

In individuals with FTO risk alleles, which type of diet would worsen diabetes risk the most?

• A. High protein

• B. Low-calorie

• C. High-fat, high-sugar

• D. Mediterranean

Which transporter is responsible for insulin-stimulated glucose uptake in muscles?

• A. GLUT1

• B. GLUT2

• C. GLUT4

• D. GLUT5

CAPN10 contributes to glucose metabolism by:

• A. Increasing glucagon levels

• B. Externalizing GLUT4 vesicles for glucose uptake

• C. Producing insulin directly

• D. Inhibiting mitochondrial respiration

In nutrigenomics, which epigenetic mechanism is most often influenced by diet?

• A. DNA methylation

• B. RNA splicing

• C. DNA replication

• D. Chromosome duplication

Nutrigenomics studies how food interacts with our genes.

• TRUE

• FALSE

Which dietary pattern is most beneficial for carriers of the Ala12 variant in PPARG?

• A. High-sugar, low-fat diet

• B. Ketogenic diet

• C. High-saturated-fat diet

• D. High-fiber, polyunsaturated-fat diet

Gene expression can be influenced by what we eat.

• TRUE

• FALSE

Which genotype at TCF7L2 rs7903146 is most strongly linked to increased T2D risk?

• A. CC

• B. CT

• C. TT

• D. GG