Hematology Quiz 1

Which of the following is a critical cofactor for delta-aminolevulinic acid dehydratase during heme synthesis?

• Zinc

• Iron

• Magnesium

• Copper

Which of the following signaling pathways is pivotal in thrombopoietin-mediated megakaryocyte differentiation?

• JAK-STAT pathway

• NF-κB pathway

• MAPK pathway

• PI3K-AKT pathway

The transcription factor PU.1 is essential for the lineage commitment of:

• Megakaryocytes

• Myeloid cells

• Erythroid cells

• Lymphoid cells

In the bone marrow niche, osteoblasts primarily regulate:

• Megakaryopoiesis

• Granulopoiesis

• HSC quiescence

• Erythropoiesis

During ineffective erythropoiesis in thalassemia, the predominant cause of apoptosis is dysregulation of:

• BCL-2 family proteins

• Fas/FasL pathway

• Caspase-9 activation

• p53 upregulation

Which of the following cell surface receptors mediates hepcidin binding, regulating iron export from enterocytes and macrophages?

• Transferrin receptor 1

• Divalent metal transporter 1 (DMT1)

• Ferroportin

• HFE protein

Which of the following best describes the erythroid maturation stage where hemoglobin synthesis peaks?

• Proerythroblast

• Basophilic erythroblast

• Polychromatic erythroblast

• Orthochromatic erythroblast

The enzyme glucose-6-phosphate dehydrogenase is vital in red cells for the generation of:

• ATP

• NADPH

• 2,3-BPG

• Lactate

What is the principal mechanism leading to neutrophil egress from the bone marrow storage pool into circulation?

• Downregulation of CXCR4

• Upregulation of G-CSF receptor

• Desensitization to SCF

• Activation of integrins

Which of the following best explains why mature RBCs are incapable of synthesizing proteins?

• Loss of mitochondria

• Loss of ribosomes

• Loss of Golgi apparatus

• All of the above