RMO MS P37 22 Juni - Frakture Vertebra + Osteomyelitis

What is the main pathophysiology of acute hematogenous osteomyelitis?

• Eosinophil infiltration and IgE production

• Perforation of the periosteum due to increased intramedullary pressure

• Mast cell activation and histamine release

• Bone destruction due to vitamin D deficiency

What is the most characteristic X-ray finding in chronic osteomyelitis?

• Diffuse osteopenia

• Sequestrum and involucrum

• Multiple osteosclerotic lesions

• Spiral fracture

What is the most specific laboratory indicator for osteomyelitis?

• ESR

• CRP

• Procalcitonin

• Bone tissue culture

What is the most common pathogen causing hematogenous osteomyelitis in children?

• Pseudomonas aeruginosa

• Mycobacterium tuberculosis

• Staphylococcus aureus

• Candida albicans

The most sensitive adjunct examination for early phase osteomyelitis is?

• X-ray

• CT-scan

• MRI

• Bone scintigraphy

What is the characteristic radiological feature of sequestrum?

• Hypodense area without cortex

• Solid radioopaque mass within osteolytic lesion

• Extensive calcification in soft tissue

• Round lesion with smooth edges

Which is the best initial empirical therapy for MRSA osteomyelitis?

• Ceftriaxone

• Linezolid

• Clindamycin

• Vancomycin

What is the characteristic of vertebral osteomyelitis compared to other forms?

• Generally involves the metaphysis

• Local pain accompanied by paralysis

• Only affects children

• Does not require MRI

What distinguishes MSSA therapy from MRSA therapy?

• MRSA is sensitive to amoxicillin

• MSSA cannot form biofilm

• MRSA requires non-beta-lactam antibiotics

• MSSA is harder to diagnose

In a child with distal femur osteomyelitis due to MSSA, the first-line therapy is?

• Vancomycin IV

• Cefazolin IV

• Ciprofloxacin IV

• Metronidazole IV