Abrams Chapter 24

What is the mechanism of action of most antifungal drugs like amphotericin B?

• Inhibiting bacterial wall synthesis

• Blocking DNA replication

• Binding to ergosterol in fungal cell membranes

• Increasing pH in fungal cells

Which antifungal is considered the drug of choice for severe systemic fungal infections?

• Fluconazole

• Amphotericin B

• Griseofulvin

• Nystatin

What is a common adverse effect of amphotericin B?

• Hypertension

• Nephrotoxicity

• Hyperglycemia

• Anemia

How is nystatin typically administered for oral candidiasis?

• Oral tablet

• Topical cream

• Swish and swallow suspension

• IV infusion

Important lab values to monitor in a patient receiving amphotericin B include:

• Renal function, electrolytes, and liver enzymes

• Blood glucose and HbA1c

• Thyroid function tests

• Serum amylase and lipase

Fluconazole is commonly used to treat:

• Malaria

• Oral thrush and vaginal candidiasis

• MRSA

• Tuberculosis

What is a potential adverse effect of fluconazole?

• Hypernatremia

• Hepatotoxicity

• Bradycardia

• Drowsiness

Griseofulvin is used primarily to treat:

• Tinea infections (ringworm)

• Influenza

• Herpes

• Candida bloodstream infections

Which antifungal agent is available in both oral and intravenous formulations?

• Nystatin

• Fluconazole

• Terbinafine

• Griseofulvin

What is the primary concern with long-term antifungal therapy?

• Hyperactivity

• Nephrotoxicity and hepatotoxicity

• Increased salivation

• Dehydration