RMO MS P38 26 Juni - Giant Cell Tumor and Enchondroma

A 25-year-old woman presents with knee pain and mild swelling. X-ray reveals a lytic lesion in the epiphysis of the distal femur, with a 'soap bubble' appearance. What is the most likely diagnosis?

• Osteosarcoma

• Giant cell tumor

• Enchondroma

• Chondroblastoma

• Fibrous dysplasia

Which of the following locations is most commonly affected by Giant Cell Tumor?

• Diaphysis of long bones

• Vertebral bodies

• Epiphysis of long bones

• Skull base

• Sternum

A 30-year-old man presents with a painless swelling of the proximal phalanx of his ring finger. Imaging reveals a well-defined, central lytic lesion without periosteal reaction. What is the most likely diagnosis?

• Giant cell tumor

• Osteoid osteoma

• Enchondroma

• Ewing sarcoma

• Osteochondroma

Histological examination of a giant cell tumor shows:

• Cartilage islands within a hyaline matrix

• Small round blue cells

• Sheets of multinucleated giant cells with mononuclear stromal cells

• Trabeculae of immature bone

• Spindle-shaped fibroblasts

Which gene mutation is most commonly associated with enchondroma?

• TP53

• IDH1/IDH2

• RB1

• PTEN

• BRAF

Which of the following is a known complication of enchondroma?

• Metastasis to lungs

• Transformation into chondrosarcoma

• Renal failure

• Pancytopenia

• Avascular necrosis

Which treatment is typically used for symptomatic Giant Cell Tumor?

• Chemotherapy only

• Radiation therapy

• Curettage and bone grafting

• NSAIDs and physical therapy

• Amputation

A 35-year-old female with a giant cell tumor of the distal radius undergoes curettage. What is the most appropriate adjunct to reduce recurrence?

• Oral antibiotics

• Denosumab

• Bisphosphonates

• Cryotherapy

• Radiation therapy

Which imaging modality is most sensitive for detecting recurrence of giant cell tumor?

• Plain radiograph

• CT scan

• Ultrasound

• MRI

• Bone scan

In which of the following syndromes are multiple enchondromas seen?

• Li-Fraumeni syndrome

• Ollier disease

• McCune-Albright syndrome

• Marfan syndrome

• Gardner syndrome