Pharm: Antibiotics

Penicillins MOA

• Inhibits protein synthesis

• Inhibits cell wall synthesis

• Inhibits folate production

• Inhibits nucleic acid synthesis

Penicillin indications

• G+

• G+ anaerobes

• Broad spectrum

• G-

Penicillins common side effects

• Nephrotixicity

• N/V/D

• Ataxia

• Abdominal pain

• Hepatotoxicity

Penicillins serious side effects

• Seizures

• C Diff

• Red man syndrome

• Steven’s-Johnson syndrome

• Hepatotoxicity

Allergic reaction to penicillins

• Rash

• Possible anaphylaxis

• Inflammatory conditions

• Nausea

• Fever

If allergic to one penicillin,

• Allergic to amoxicillin

• Allergic to ampicillin

• Allergic to all penicillins

• Allergic to aminoglycosides

How many generations of penicillins are there

• 2

• 3

• 4

• 5

Cephalosporins MOA

• Inhibits protein synthesis

• Inhibits cell wall synthesis

• Inhibits folate production

• Inhibits nucleic acid synthesis

Cephalosporins indications

• G+

• G+ anaerobes

• Broad spectrum

• G-

Cephalosporins common side effects

• Nephrotixicity

• N/V/D

• Ataxia

• Abdominal pain

• Hepatotoxicity