
Pain & Inflammation Part 1.3
Quiz
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Other
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University
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Practice Problem
•
Hard
Benj Almero
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17 questions
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1.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Indomethacin, an acetic acid derivative, is noted for what characteristic and uses?
It is less potent than aspirin and primarily used for mild pain.
It is a selective COX-2 inhibitor with a long half-life.
It is the most potent inhibitor of prostaglandin synthesis (COX-1) and is used for acute gouty arthritis and ankylosing spondylitis.
It is primarily an analgesic with no anti-inflammatory effect.
2.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Besides inhibiting prostaglandin synthesis, what other enzymes may Indomethacin inhibit?
COX-2 and TXA2.
Phospholipase A and C.
Interleukin-1 and Interleukin-6.
Nitric oxide synthase and adhesion molecules.
3.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Why are topical forms of Indomethacin often preferred, despite its oral absorption?
It is poorly absorbed orally.
It is not bound to plasma proteins.
It is highly bound to plasma proteins, so topical forms are often preferred for local analgesic/anti-inflammatory effects.
It has a very short half-life.
4.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Which of the following are listed as adverse effects of Indomethacin?
Agranulocytosis and aplastic anemia.
GI problems, severe migraine, confusion, depression, and risk of fluid retention.
Occult bleeding and renal tubular necrosis without hepatic issues.
Diarrhea and abdominal pain (only).
5.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
Indomethacin is contraindicated in which patient populations?
Patients with diabetes and hypertension.
Patients with peptic ulcer and gastrointestinal irritation.
Pregnant patients (due to premature closure of the patent ductus arteriosus, PDA, in the fetus) and in patients with psychosis.
Children with chickenpox or influenza B virus infection.
6.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is noted about Sulindac?
It is an active drug that is converted into a prodrug in the liver.
It has a distinct indication and toxicity profile from indomethacin.
It is a prodrug closely related to indomethacin, converted to its active form in the liver, with similar indications and toxicity profile.
It is an anthranilic acid derivative with a short half-life.
7.
MULTIPLE CHOICE QUESTION
30 sec • 1 pt
What is noted about Diclofenac?
It is contraindicated in nursing mothers but safe for children and pregnant women.
It does not accumulate in synovial fluid.
It accumulates in synovial fluid after oral administration, high doses can impair renal function, and it is contraindicated in children, pregnant women, and nursing mothers.
It is primarily used to replace morphine for post-surgical pain.
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