SGLT2 Inhibitors Quiz

Which of the following best describes the primary mechanism of action of SGLT2 inhibitors?

• Increases insulin secretion from pancreatic beta cells

• Inhibits glucose absorption in the intestines

• Reduces glucose reabsorption in the proximal renal tubule

• Increases hepatic glucose production

• Stimulates glucagon secretion

Inhibition of SGLT2 leads to which of the following physiological outcomes?

• Increased glucose reabsorption in the kidneys

• Increased glucose excretion in urine

• Decreased urine output

• Increased hepatic glycogen synthesis

• Decreased plasma ketone levels

Which of the following is NOT listed as a benefit of SGLT2 inhibitors beyond lowering blood sugar in the slide?

• Reduces the risk of heart failure

• Lowers blood pressure

• Increases appetite

• Promotes weight loss

• Protects the kidneys

What is the protein responsible for the reabsorption of glucose in the proximal renal tubule that is inhibited by SGLT2 inhibitors?

• SGLT2 inhibitor

• SGLT1

• SGLT2

• Insulin receptor

• Glucokinase

Which of the following effects is achieved due to reduced glucose reabsorption by SGLT2 inhibitors in patients with diabetes?

• Increase in blood sugar (glycemic levels)

• Reduction in blood sugar (glycemic levels)

• Increase in insulin resistance

• Increase in hepatic glucose output

• Decrease in urinary glucose excretion