Dementia Quiz

Which of the following cerebrospinal fluid (CSF) biomarker patterns is most consistent with Alzheimer's disease?

• Decreased total tau, increased Aβ42

• Increased phosphorylated tau, decreased Aβ42

• Increased Aβ42, decreased phosphorylated tau

• Normal tau, decreased Aβ40

Which genetic mutation is most commonly associated with early-onset familial Alzheimer's disease?

• APOE ε4

• PSEN1

• MAPT

• GRN

In amyloid PET imaging, which of the following statements is TRUE?

• A negative scan excludes all types of dementia

• A positive scan confirms clinical Alzheimer's disease

• A negative scan essentially rules out Alzheimer's pathology

• Amyloid PET can differentiate between Alzheimer's and vascular dementia

In which dementia are 'knife-edge' gyri on MRI classically described?

• Alzheimer's disease

• Vascular dementia

• Frontotemporal dementia

• Lewy body dementia

What are the newer treatment options for Alzheimer's disease?

• Donamemab

• Lecanemab

• Rituximab

• Alemtuzumab

Which of the following is a synucleopathy?

• Alzheimer's disease

• Lewy body dementia

• Frontotemporal dementia

• Vascular dementia

Which of the following is considered 3R+4R taupathy?

• Alzheimer's disease

• GGT

• PSP

• Picks disease

Which FTD pathology is associated exclusively with behavioural variant of FTD and sometimes associated with very young onset disease?

• TDP-43

• FUS

• MAPT

Choose the correct options regarding imaging findings of FTD.

• Semantic variant-atrophy of the anterior inferior temporal lobe, with an asymmetric (left more than right) pattern- True

• PPA-nf variant- Asymmetric perisylvian and anterior insular atrophy with the dominant language hemisphere most affected- True

• Atrophy pattern observed in behavioral variant FTLD cannot vary by underlying pathology - True

• Patients with the C9orf72 variation exhibit less psychotic features -True