Controlled Drug Delivery System

Q.1 Rate determining step for controlled release delivery system is

• 1. a) Absorption

• 1. b) Drug release from dosage form

• 1. c) Both

• 1. d) None

Q.2 More than 95 % drugs are absorbed by this mechanism.

• 1. a. Dissolution

• 1. b. Diffusion

• 1. c. passive diffusion

• 1. d. direct absorption

Q.3.The biological factor influencing the design and act of controlled release product is

• 1. a) Partition coefficient

• 1. b) Absorption

• 1. c) Molecular size

• 1. d) Solubility

Q.4. Drugs with ———therapeutic index are unsuitable for incorporation in controlled release formulation

• 1. a. High

• 1. b. low

• 1. c. Moderate

• 1. d. None of this

Q.5. Zero order release kinetics is attained in

• 1. a.sustain release

• 1. b.controlled release

• 1. c.Enteric coating

• 1. d.Immediate coating

Q.6. Diffusion controlled Modified Release (MR) system consist of

• 1. a. Hydrophobic matrix systems

• 1. b. Hydrophobic reservior systems

• 1. c. Hydrophillic matrix systems

• 1. d. Both a&b

Q.7 Drug having molecular weight —————— is good candidate for controlled release dosage form

• 1. a) More than 2000 dalton

• 1. b) Less than 600 dalton

• 1. c) Over and above 1000 dalton

• 1. d) None of the above

Q.8. Release kinetics from dissolution control system is governed by

• 1. a. Fick’s law of diffusion

• 1. b. Noyes Whitney equation

• 1. c. Zero order

• 1. d, First order

Q.9. For a drug to be formulated in to controlled/modified release dosage form it’s Margin of safety should be—-

• 1. a. Very low

• 1. b. Very high

• 1. c. Normal

• 1. d. None of above

Q.10. Ideally, the drug should have half-life to be formulated in controlled release dosage

• 1. a. 3-4hrs

• 1. b. 1-2 hrs

• 1. c. 6-7 hrs

• 1. d. 9-10 hrs