Parkinson's and Huntington's Disease Quiz

Which part of the brain is primarily affected in Parkinson’s disease?

• Cerebellum

• Substantia nigra

• Hippocampus

• Thalamus

Parkinson's disease is associated with a deficiency of which neurotransmitter?

• Serotonin

• Acetylcholine

• Dopamine

• Glutamate

Alpha-synuclein accumulation in neurons leads to the formation of:

• Neurofibrillary tangles

• Lewy bodies

• Amyloid plaques

• Tau tangles

The typical onset of Parkinson's disease is most commonly in:

• Childhood

• Teenage years

• Middle-aged and elderly

• Infancy

One of the earliest and most common symptoms of Parkinson's disease is:

• Paralysis

• Vision loss

• Resting tremor

• Severe memory loss

Which gene is associated with mutations leading to Parkinson’s disease?

• HTT

• APP

• SNCA (Alpha-synuclein)

• MAPT

Which of the following is NOT a symptom of Parkinson’s disease?

• Muscular rigidity

• Postural instability

• Hyperreflexia

• Resting tremor

What is the role of superoxide dismutase in Parkinson’s disease?

• Generates dopamine

• Prevents iron accumulation

• Breaks down superoxide anion

• Promotes alpha-synuclein aggregation

Neuromelanin forms in dopaminergic neurons due to the activity of:

• Tyrosinase

• Catalase

• Peroxidase

• Superoxide dismutase

Iron accumulation in Parkinson’s disease is a result of:

• Excess iron intake

• Genetic iron storage diseases

• Insufficient dopamine synthesis

• Inflammation