Transfusion Reactions Quiz

Which of the following is most commonly responsible for acute hemolytic transfusion reactions (AHTRs)?

• ABO incompatibility

• Rh incompatibility

• Iron overload

• Delayed hypersensitivity

What is the hallmark laboratory finding in an acute hemolytic transfusion reaction?

• Leukocytosis

• Hemoglobinuria

• Hypocalcemia

• Elevated albumin

Delayed hemolytic transfusion reactions (DHTRs) typically occur:

• Within 30 minutes of transfusion

• Within 24 hours

• 3-14 days after transfusion

• More than a month later

Which of the following is a key feature of hyperhemolysis syndrome?

• Only donor red cells are destroyed

• Only recipient red cells are destroyed

• Both donor and recipient red cells are destroyed

• No hemolysis occurs

Hyperhemolysis is most commonly reported in patients with:

• Thalassemia

• Aplastic anemia

• Sickle cell disease

• Autoimmune hepatitis

Which of the following treatments is often avoided in hyperhemolysis syndrome?

• Intravenous immunoglobulin (IVIG)

• Corticosteroids

• Further transfusions

• Erythropoietin

Fever, chills, and flank pain are classic signs of an acute hemolytic transfusion reaction.

• TRUE

• FALSE

In delayed hemolytic transfusion reactions, the direct antiglobulin test (DAT) is often negative.

• TRUE

• FALSE

Hyperhemolysis involves an exaggerated destruction of red blood cells, sometimes dropping hemoglobin levels below pre-transfusion levels.

• TRUE

• FALSE

Hyperhemolysis often presents with reticulocytosis as a compensatory mechanism.

• TRUE

• FALSE