Febrile Neutropenia and Chemotherapy Toxicity Quiz

What is the most common dose-limiting toxicity of chemotherapy?

• Bone marrow suppression (myelosuppression)

• Liver toxicity

• Cardiac toxicity

• Renal toxicity

Which of the following is NOT a type of cytopenia caused by bone marrow suppression?

• Anemia

• Thrombocytopenia

• Leukopenia

• Hyperglycemia

What is the usual desired WBC count before starting chemotherapy?

• > 1000

• > 3000

• > 5000

• > 10,000

How is Absolute Neutrophil Count (ANC) calculated?

• (%neutrophils + %bands) x WBC / 100

• (%lymphocytes + %monocytes) x WBC / 100

• (%eosinophils + %basophils) x WBC / 100

• (%neutrophils + %eosinophils) x WBC / 100

What ANC value defines neutropenia?

• ANC < 1000

• ANC < 1500

• ANC < 500

• ANC < 2000

What is the typical nadir period for neutropenia after chemotherapy?

• 1-3 days

• 3-4 weeks

• 10-14 days

• 6-8 weeks

Which chemotherapy agents are associated with a nadir of 4-6 weeks post-chemo?

• Bleomycin, carmustine, lomustine, vincristine

• Doxorubicin, cyclophosphamide, methotrexate

• Paclitaxel, docetaxel, cisplatin

• Etoposide, gemcitabine, vinblastine

What temperature defines febrile neutropenia?

• ≥ 99°F

• ≥ 100.4°F for 1 hour or ≥ 101°F once

• ≥ 102°F for 30 minutes

• ≥ 98.6°F for 2 hours

Which of the following is NOT a common hematologic malignancy associated with febrile neutropenia?

• Leukemia

• Lymphoma

• Multiple myeloma

• Melanoma

What is a primary goal in the treatment of febrile neutropenia?

• Prevent infections, morbidity, and mortality

• Increase platelet count

• Reduce blood pressure

• Improve liver function