Pharm RA/Gout

What are some of the contraindications for Methotrexate?

• Pregnancy and lactation

• High blood pressure

• Diabetes

• Asthma

What daily supplement is recommended to counteract folic acid deficiency caused by Methotrexate?

• Vitamin D 10-20mg

• Folic acid 1-5mg

• Calcium 500mg

• Iron 10mg

Which of the following is a known interaction with Leflunomide?

• Aspirin

• Warfarin

• Ibuprofen

• Acetaminophen

Which of the following is NOT an adverse drug reaction (ADR) of Tofacitinib?

• Bone marrow suppression

• Hepatic issues

• Increased appetite

• Lipid abnormalities

What type of antibody is Adalimumab?

• IgA

• IgM

• IgG1

• IgE

What is the mechanism of action (MOA) of Rituximab?

• Anti-CD20 monoclonal antibody

• Anti-CD19 monoclonal antibody

• Anti-CD22 monoclonal antibody

• Anti-CD25 monoclonal antibody

Which of the following is an ADR of colchicine?

• Lupus like syndrome

• Increased risk of infection

• Neuromuscular toxicity

• Teratogencity

Allopurinol is used in the treatment of:

• Acute gout flare

• Chronic gout

• Acute flare of RA

• Chronic management of RA

What is the BBW for Febuxostat?

• Hepatotoxcity

• Tertogenicity

• CV related death

• Severe bleeding