Medical and Biochemistry Quiz

What is the major iron storage compound?

• Hemosiderin

• Ferritin

• Siderotic granules

• Transferrin

A 72-year-old woman has the following results: Hemoglobin: 6 g/dL MCV: 114 fL MCH: 39 pg MCHC: 34 g/dL Oval macrocytes on Wright stain Serum B12: 55 pg/mL (Normal: 200–1000 pg/mL) Serum folate: 7 ng/mL (Normal: 1–10 ng/mL) Anti-intrinsic factor antibodies: positive What is the most likely diagnosis?

• Folate deficiency

• Liver disease

• Pernicious anemia

• Reticulocytosis

Which condition results from decreased synthesis of globin chains?

• Beta-thalassemia

• Hemoglobin C disease

• Hemoglobin M

• Sickle cell disease

What is the normal myeloid-to-erythroid (M:E) ratio for an adult bone marrow?

• 1:1.5

• 3:1

• 5:1

• 9:1

The failure of granulocytes to develop past the band or two-lobed stage is characteristic of:

• Bernard-Soulier syndrome

• Chediak-Higashi syndrome

• May-Hegglin anomaly

• Pelger-Huet anomaly

A patient has markedly elevated WBC count with neutrophilia, left shift, toxic granulation, vacuoles, Döhle bodies, and increased LAP score. What is the most likely diagnosis?

• Chronic lymphocytic leukemia

• Chronic myelogenous leukemia

• Leukemoid reaction

• Pelger-Huet anomaly

Lymphocytes with cytoplasmic projections and a positive tartrate-resistant acid phosphatase stain are most likely found in:

• Chronic lymphocytic leukemia

• Acute lymphocytic leukemia

• Sezary syndrome

• Hairy cell leukemia

Plasma cells evolve from which cell line?

• Lymphocytic

• Monocytic

• Myelocytic

• Megakaryocytic

A peripheral smear stained with Prussian blue shows siderocytes. On a Wright-stained smear, these would appear as:

• Basophilic stippling

• Howell-Jolly bodies

• Heinz bodies

• Pappenheimer bodies

A “dry tap” bone marrow aspiration is most commonly associated with:

• Iron deficiency anemia

• Myelofibrosis

• Vitamin B12 deficiency

• Acute lymphoblastic leukemia