Sept 25

What is the "East Asian Paradox" in antiplatelet therapy for patients with coronary artery disease?

• Higher ischemic risk and higher bleeding risk compared to Western populations

• Lower ischemic risk and lower bleeding risk compared to Western populations

• Lower ischemic risk but higher bleeding risk compared to Western populations

• Higher ischemic risk but lower bleeding risk compared to Western populations

• Equal ischemic and bleeding risk compared to Western populations

According to the position statement, which P2Y12 inhibitor is generally preferred for East Asian patients with acute coronary syndrome (ACS) undergoing PCI with high bleeding risk?

• Ticagrelor

• Prasugrel

• Clopidogrel

• Cangrelor

• Aspirin monotherapy

What is the recommended duration of dual antiplatelet therapy (DAPT) in East Asian patients with high bleeding risk after PCI according to the JACC Asia 2025 update?

• 12 months without interruption

• 6 months minimum

• 3 to 6 months with subsequent monotherapy

• 1 month only

• DAPT duration is not recommended

In East Asians, the higher bleeding risk is partly explained by:

• Genetic polymorphisms affecting drug metabolism

• Lower body weight and smaller vessel size

• Higher prevalence of cerebral small vessel disease

• All of the above

• None of the above

In the position statement, what is the suggested approach for antiplatelet therapy in East Asian patients undergoing elective PCI with low ischemic risk?

• Prolonged DAPT (at least 12 months)

• Short DAPT (1-3 months) followed by monotherapy with P2Y12 inhibitor

• Aspirin monotherapy from the start

• Clopidogrel alone without aspirin

• No antiplatelet therapy needed

Which of the following is recommended for East Asian patients with a history of ischemic stroke who require antiplatelet therapy?

• Prasugrel is the preferred P2Y12 inhibitor

• Ticagrelor use is contraindicated

• Clopidogrel is generally preferred due to bleeding concerns

• Dual antiplatelet therapy should be lifelong

• Aspirin alone is sufficient

Which statement best reflects the approach to antiplatelet therapy in East Asian patients according to the 2025 update?

• Applying Western guidelines without modification is appropriate

• East Asians generally tolerate prolonged DAPT better than Western patients

• Personalized therapy considering ethnic differences in ischemic and bleeding risk is emphasized

• Aspirin is ineffective in East Asians

• Ticagrelor should be avoided in all East Asian patients

What is the first-line treatment for sustained monomorphic ventricular tachycardia (VT) in a hemodynamically stable patient?

• Immediate synchronized cardioversion

• Intravenous amiodarone

• Intravenous adenosine

• Beta-blocker administration

• Oral mexiletine

Which electrolyte abnormality is most commonly associated with ventricular arrhythmias in critically ill cardiac patients?

• Hypercalcemia

• Hypokalemia

• Hypernatremia

• Hyponatremia

• Hypomagnesemia

What is the role of implantable cardioverter-defibrillators (ICDs) in the management of ventricular arrhythmias in cardiac ICU patients?

• Immediate therapy during an acute VT episode

• Primary prevention in all cardiac ICU patients

• Secondary prevention in patients with prior sustained VT or VF

• Replacement for antiarrhythmic drugs in unstable patients

• Only used in heart transplant patients