Lorenzo's Oil Movie Quiz

What is the full name of the genetic disease that affects Lorenzo Odone in the movie?

• Adrenomyeloneuropathy (AMN)

• Adrenoleukodystrophy (ALD)

• Myelin Degenerative Disorder (MDD)

• Leukodystrophy X-linked (LDX)

The illness that afflicted Lorenzo primarily targets which part of the nervous system?

• Axons

• Myelin sheath

• Synaptic cleft

• Dendrites

What is the primary substance that accumulates to toxic levels in the body due to the genetic defect?

• Cholesterol

• Phospholipids

• Glucose

• Very-long-chain fatty acids (VLCFAs)

The oil created by Lorenzo's parents was a combination of which two fatty acids?

• Oleic acid and Linoleic acid

• Lauric acid and Palmitic acid

• Erucic acid and Oleic acid

• Stearic acid and Myristic acid

How did Lorenzo's Oil theoretically work to reduce the levels of the toxic substance in the body?

• It directly broke down the accumulated very-long-chain fatty acids.

• It provided the missing enzyme needed to metabolize the substance.

• It blocked the body's ability to produce fatty acids altogether.

• It inhibited the enzyme responsible for synthesizing the toxic fatty acids.

What part of the brain is primarily affected by the breakdown of myelin in ALD, leading to the symptoms seen in Lorenzo?

• Cerebellum

• Brainstem

• Frontal lobe

• Cerebral white matter

What was the initial, most common symptom Lorenzo's parents noticed that led them to seek medical advice?

• Skin pigmentation changes

• Loss of hearing and behavioral problems

• Unexplained fevers and fatigue

• Sudden weight gain and increased appetite

The movie highlights the role of which cell type in the process of demyelination?

• Neurons

• Schwann cells

• Astrocytes

• Oligodendrocytes

What type of inheritance pattern does ALD follow?

• Autosomal dominant

• X-linked recessive

• Autosomal recessive

• Mitochondrial

Tags

NGSS.HS-LS3-1

NGSS.HS-LS3-2

Which of the following is an accurate description of the parents' approach to finding a treatment for their son?

• They relied solely on conventional medical research and doctors' advice.

• They sought out an experimental drug that was already in clinical trials.

• They were a chemist and a geneticist who used their professional knowledge to find a cure.

• They independently researched the biochemistry of the disease and worked with scientists to develop a novel treatment.