DNA Repair SI

What type of repair pathway would repair replication errors?

• Base Excision Repair

• Nucleotide Excision Repair

• Mismatch Repair

• Homologous Recombination

What type of repair pathway would repair oxidative damage?

• Base Excision Repair

• Nucleotide Excision Repair

• Mismatch Repair

• Homologous Recombination

What type of repair pathway would repair UV-induced damage?

• Base Excision Repair

• Nucleotide Excision Repair

• Mismatch Repair

• Homologous Recombination

Who am I? I recognize a damaged nucleotide(s) that was damaged by oxidative damaged or alkylation & will flip the base out to cleave it out

• DNA glycosylase

• XPC

• EXO1

• APE1

Who am I? I recognize abasic sites and cleave the abasic site to remove the sugar phosphate group & create a nucleotide gap

• OGG1

• XPC

• EXO1

• APE1

Who am I? I bind the bulky lesion after it has been recognized by other proteins (I am sorry I know this one is hard but if you can draw out this pathway you will be so set)

• XPA

• XPG

• XPF

• XPC

Choose all that are a source of DSBs (double-strand breaks)

• Ionizing radiation

• ROS

• Replication fork collapse

• CRISPR-Cas9 system

If a cancer patient takes cisplatin (anti-tumor drug), what pathways will begin repair in the presence of interstrand crosslinks that are induced? (Multiple answers)

• NER

• BER

• Translesion synthesis (TLS)

• HR

Who am I? I cap the ends of DSB for protection

• Ku

• MRN

• RAD51

• BRCA2

Who am I? I sense double-stranded DNA damage such as a DSB

• ATM

• ATR

• OGG1

• APE1