What is the primary target of aminoglycoside toxicity?

• Cochleo-vestibular systems

• Liver and kidneys

• Heart and lungs

• Nervous system

Which of the following is a common sign of platinum-induced ototoxicity?

• Nausea

• Tinnitus

• Dizziness

• Ringing in the ears

What is the mechanism of action of aminoglycosides in causing ototoxicity?

• Inhibition of protein synthesis

• Free radical generation

• Blocking ion channels

• Disruption of DNA replication

Which of the following agents is known for causing reversible ototoxicity?

• Furosemide

• Streptomycin

• Salicylates

• Cisplatin

What is a common symptom of salicylate ototoxicity?

• Severe vertigo

• Bilateral symmetrical hearing loss

• Tinnitus

• Nausea and vomiting

What is the primary effect of quinine on the cochlea?

• Enhanced cochlear mechanics

• Direct damage to the auditory nerve

• Increased blood flow

• Inhibition of hair cell transduction

What type of hearing loss is associated with aminoglycoside-induced ototoxicity?

• Conductive hearing loss

• Bilateral sensorineural hearing loss

• Unilateral sensorineural hearing loss

• Reversible hearing loss

Which audiometric test is recommended for detecting ototoxicity?

• High-frequency audiometry

• Speech audiometry

• Tympanometry

• Pure tone audiometry

What is the primary cause of hearing loss due to salicylates?

• Reversible biochemical changes

• Increased blood flow

• Permanent cell death

• Structural damage to hair cells

What is a common characteristic of hearing loss from cisplatin?

• Unilateral and reversible

• Bilateral and progressive

• Conductive and temporary

• Sensorineural and mild