Drug Bio-transformation Quiz

Which tissue has the greatest capacity to bio-transform drugs?

• Brain

• Kidney

• Liver

• Lung

• Skin

Biotransformation of drugs is primarily directed to:

• Activate the drug

• Inactivate the drug

• Convert lipid soluble drugs into nonlipid soluble metabolites

• Convert nonlipid soluble drugs into lipid soluble metabolites

Which of the following is a prodrug?

• Hydralazine

• Clonidine

• Captopril

• Enalapril

What is a prodrug?

• The prototype member of a class of drugs

• The oldest member of a class of drugs

• An inactive drug that is transformed in the body to an active metabolite

• A drug that is stored in body tissues and is then gradually released in the circulation

Which of the following cytochrome P450 isoenzymes is involved in the metabolism of the largest number of drugs in human beings and has been implicated in some dangerous drug interactions?

• CYP 3A4

• CYP 2C9

• CYP 2E1

• CYP 1A2

The most common nonsynthetic reaction for drugs and their metabolites is:

• Glucuronidation

• Acetylation

• Methylation

• Oxidation

Which of the following is a phase II drug metabolizing reaction?

• Acetylation

• Hydrolysis

• Oxidation

• Reduction

Microsomal enzyme induction can be a cause of:

• Tolerance

• Physical dependence

• Psychological dependence

• Idiosyncrasy

The following drug metabolizing reaction is entirely nonmicrosomal:

• Glucuronide conjugation

• Acetylation

• Oxidation

• Reduction

What does the induction of drug metabolizing enzymes involve?

• A conformational change in the enzyme protein to favour binding of substrate molecules

• Expression of enzyme molecules on the surface of hepatocytes

• Enhanced transport of substrate molecules into hepatocytes

• Increased synthesis of enzyme protein